tetanus toxin

tetanus toxin
(= tetanospasmin)
Neurotoxin released by Clostridium tetani ; becomes active when peptide cleaved proteolytically to heavy (100 kD) and light (50 kD) chains held together by disulphide bond. Heavy chain binds to disialogangliosides (GD2 and GD1b), and part of the peptide (the amino-terminal B-fragment) forms a pore: light chain is a zinc endopeptidase that specifically attacks synaptobrevin, to block neurotransmitters. See also botulinum toxin.

Dictionary of molecular biology. 2004.

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